RNA therapeutics
E621880
RNA therapeutics are medical treatments that use RNA molecules to modulate gene expression or protein production for preventing, treating, or curing disease.
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf |
biomedical technology
ⓘ
molecular medicine approach ⓘ therapeutic modality ⓘ |
| aimsTo |
cure disease
ⓘ
prevent disease ⓘ treat disease ⓘ |
| commonlyUses |
conjugate delivery systems
ⓘ
lipid nanoparticles ⓘ polymeric nanoparticles ⓘ |
| enables |
personalized medicine
ⓘ
rapid vaccine development ⓘ |
| facesChallenge |
RNA instability
ⓘ
immune activation ⓘ off-target effects ⓘ targeted delivery ⓘ |
| includesSubtype |
RNA aptamer therapeutics
ⓘ
RNA vaccine ⓘ antisense oligonucleotide therapeutics ⓘ guide RNA-based genome editing therapeutics ⓘ mRNA therapeutics ⓘ miRNA therapeutics ⓘ self-amplifying RNA therapeutics ⓘ siRNA therapeutics ⓘ |
| isFieldOf |
drug development
ⓘ
translational research ⓘ |
| mechanismOfAction |
gene silencing
ⓘ
gene upregulation ⓘ protein replacement ⓘ receptor binding ⓘ splicing modulation ⓘ translation inhibition ⓘ |
| regulatoryApprovedExample |
COVID-19 mRNA vaccines
ⓘ
eteplirsen NERFINISHED ⓘ givosiran NERFINISHED ⓘ inclisiran NERFINISHED ⓘ inotersen NERFINISHED ⓘ mipomersen NERFINISHED ⓘ nusinersen NERFINISHED ⓘ patisiran NERFINISHED ⓘ |
| requires | delivery system ⓘ |
| targetsProcess |
gene expression
ⓘ
protein production ⓘ |
| treats |
cancer
ⓘ
genetic diseases ⓘ infectious diseases ⓘ metabolic disorders ⓘ neurological disorders ⓘ |
| usesMoleculeType | RNA ⓘ |
| usesStrategy |
chemical modification of nucleotides
ⓘ
codon optimization ⓘ formulation optimization ⓘ sequence optimization ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.