Variola virus
E617597
Variola virus is the orthopoxvirus that causes smallpox, a once-devastating human disease that was globally eradicated through vaccination efforts led by the World Health Organization.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Variola major virus | 1 |
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
human pathogen
ⓘ
orthopoxvirus ⓘ virus ⓘ |
| associatedDisease |
Variola major
NERFINISHED
ⓘ
Variola minor NERFINISHED ⓘ |
| BaltimoreClassification | Group I dsDNA viruses ⓘ |
| biosafetyLevel | BSL-4 ⓘ |
| caseFatalityRateRange | up to 30 percent for Variola major ⓘ |
| causes | smallpox ⓘ |
| clinicalFeature | fever followed by characteristic pustular rash ⓘ |
| controlMethod | vaccination with vaccinia virus ⓘ |
| currentVaccinePolicy | routine vaccination discontinued after eradication ⓘ |
| designatedAs |
bioterrorism threat agent
ⓘ
select agent ⓘ |
| DNAStrandPolarity | double-stranded ⓘ |
| entryReceptor | glycosaminoglycans on host cells ⓘ |
| enveloped | true ⓘ |
| eradicationDeclaredBy | World Health Organization NERFINISHED ⓘ |
| eradicationStatus | eradicated in the wild ⓘ |
| eradicationYear | 1980 ⓘ |
| family | Poxviridae NERFINISHED ⓘ |
| genomeSizeApproximate | about 186 kilobase pairs ⓘ |
| genomeStructure | linear DNA ⓘ |
| genomeType | double-stranded DNA ⓘ |
| genus | Orthopoxvirus NERFINISHED ⓘ |
| historicalImpact |
caused high childhood mortality
ⓘ
caused major pandemics ⓘ |
| hostRange | narrow ⓘ |
| immuneEvasionMechanism |
inhibition of host interferon responses
ⓘ
production of viral cytokine decoy receptors ⓘ |
| incubationPeriodRange | about 7 to 17 days ⓘ |
| infects | humans ⓘ |
| naturalHost | Homo sapiens ⓘ |
| order | unassigned within Poxviridae ⓘ |
| parentTaxon | Orthopoxvirus NERFINISHED ⓘ |
| primaryPrevention | vaccination ⓘ |
| primaryReservoir | humans ⓘ |
| primaryTropism |
epidermal cells
ⓘ
respiratory epithelium ⓘ |
| replicationCharacteristic | encodes its own transcription machinery ⓘ |
| replicationSite | cytoplasm ⓘ |
| taxonRank | species ⓘ |
| transmissionRoute |
aerosol
ⓘ
direct contact with lesions ⓘ respiratory droplets ⓘ |
| vaccineTypeUsed | live attenuated vaccinia virus vaccine ⓘ |
| virionShape | brick-shaped ⓘ |
| zoonotic | false ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Variola major virus