SMN complex
E564273
The SMN complex is a multiprotein assembly crucial for the biogenesis of small nuclear ribonucleoproteins (snRNPs) and proper pre-mRNA splicing, with key roles in motor neuron survival.
All labels observed (2)
| Label | Occurrences |
|---|---|
| SMN complex canonical | 1 |
| SMNc | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004695 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: SMN complex Context triple: [Survival motor neuron protein, formsComplexWith, SMN complex]
-
A.
SMN1 gene
The SMN1 gene is a human gene whose proper function is critical for motor neuron survival, and mutations in it are the primary cause of spinal muscular atrophy.
-
B.
SMN2
SMN2 is a human gene that produces a backup form of survival motor neuron protein and is a key therapeutic target in spinal muscular atrophy.
-
C.
SOD1
SOD1 is a gene encoding the antioxidant enzyme superoxide dismutase 1, whose mutations are a major known cause of familial amyotrophic lateral sclerosis (ALS).
-
D.
survival motor neuron protein
Survival motor neuron protein is an essential cellular protein required for the maintenance and function of motor neurons, whose deficiency leads to spinal muscular atrophy.
-
E.
SMND
SMND is the station code for the central Paris RER railway station Saint-Michel–Notre-Dame, a major hub near Notre-Dame Cathedral.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: SMN complex Target entity description: The SMN complex is a multiprotein assembly crucial for the biogenesis of small nuclear ribonucleoproteins (snRNPs) and proper pre-mRNA splicing, with key roles in motor neuron survival.
-
A.
SMN1 gene
The SMN1 gene is a human gene whose proper function is critical for motor neuron survival, and mutations in it are the primary cause of spinal muscular atrophy.
-
B.
SMN2
SMN2 is a human gene that produces a backup form of survival motor neuron protein and is a key therapeutic target in spinal muscular atrophy.
-
C.
SOD1
SOD1 is a gene encoding the antioxidant enzyme superoxide dismutase 1, whose mutations are a major known cause of familial amyotrophic lateral sclerosis (ALS).
-
D.
survival motor neuron protein
Survival motor neuron protein is an essential cellular protein required for the maintenance and function of motor neurons, whose deficiency leads to spinal muscular atrophy.
-
E.
SMND
SMND is the station code for the central Paris RER railway station Saint-Michel–Notre-Dame, a major hub near Notre-Dame Cathedral.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
cellular macromolecular complex
ⓘ
multiprotein complex ⓘ ribonucleoprotein assembly ⓘ |
| associatedWithDisease | spinal muscular atrophy ⓘ |
| biologicalProcess |
RNA processing
ⓘ
RNP assembly ⓘ pre-mRNA splicing ⓘ small nuclear RNA (snRNA) maturation ⓘ snRNP biogenesis ⓘ spliceosomal snRNP assembly ⓘ |
| defectLeadsTo |
aberrant pre-mRNA splicing
ⓘ
motor neuron degeneration ⓘ reduced snRNP levels ⓘ |
| essentialFor |
motor neuron survival
ⓘ
proper neuromuscular function ⓘ |
| evolutionarilyConservedIn |
invertebrates
ⓘ
vertebrates ⓘ yeast (partial functional analogs) ⓘ |
| hasComponent |
Gemin2
NERFINISHED
ⓘ
Gemin3 NERFINISHED ⓘ Gemin4 NERFINISHED ⓘ Gemin5 NERFINISHED ⓘ Gemin6 NERFINISHED ⓘ Gemin7 NERFINISHED ⓘ Gemin8 NERFINISHED ⓘ SMN protein ⓘ UNRIP protein NERFINISHED ⓘ |
| identifiedIn |
Drosophila melanogaster
NERFINISHED
ⓘ
Homo sapiens ⓘ Mus musculus NERFINISHED ⓘ |
| interactsWith |
Sm proteins
NERFINISHED
ⓘ
coilin ⓘ snRNAs ⓘ spliceosomal components ⓘ |
| locatedIn |
Cajal bodies
NERFINISHED
ⓘ
cytoplasm ⓘ gems (Gemini of Cajal bodies) NERFINISHED ⓘ nucleus ⓘ |
| molecularFunction |
RNA binding
ⓘ
chaperone activity in snRNP assembly ⓘ protein binding ⓘ |
| partOf |
RNA splicing machinery
ⓘ
spliceosomal snRNP assembly pathway ⓘ |
| regulates |
snRNP nuclear import
ⓘ
snRNP stability ⓘ spliceosome assembly ⓘ |
| requiresComponent |
SMN1 gene product
ⓘ
SMN2 gene product ⓘ |
| subcellularDistributionDependsOn | SMN protein concentration ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: SMN complex Description of subject: The SMN complex is a multiprotein assembly crucial for the biogenesis of small nuclear ribonucleoproteins (snRNPs) and proper pre-mRNA splicing, with key roles in motor neuron survival.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein
this entity surface form:
SMNc