SMN complex

E564273
cellular macromolecular complex multiprotein complex ribonucleoprotein assembly

The SMN complex is a multiprotein assembly crucial for the biogenesis of small nuclear ribonucleoproteins (snRNPs) and proper pre-mRNA splicing, with key roles in motor neuron survival.

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Observed surface forms (1)

Surface form Occurrences
SMNc 1

Statements (49)

Predicate Object
instanceOf cellular macromolecular complex ⓘ
multiprotein complex ⓘ
ribonucleoprotein assembly ⓘ
associatedWithDisease spinal muscular atrophy ⓘ
biologicalProcess RNA processing ⓘ
RNP assembly ⓘ
pre-mRNA splicing ⓘ
small nuclear RNA (snRNA) maturation ⓘ
snRNP biogenesis ⓘ
spliceosomal snRNP assembly ⓘ
defectLeadsTo aberrant pre-mRNA splicing ⓘ
motor neuron degeneration ⓘ
reduced snRNP levels ⓘ
essentialFor motor neuron survival ⓘ
proper neuromuscular function ⓘ
evolutionarilyConservedIn invertebrates ⓘ
vertebrates ⓘ
yeast (partial functional analogs) ⓘ
hasComponent Gemin2 NERFINISHED ⓘ
Gemin3 NERFINISHED ⓘ
Gemin4 NERFINISHED ⓘ
Gemin5 NERFINISHED ⓘ
Gemin6 NERFINISHED ⓘ
Gemin7 NERFINISHED ⓘ
Gemin8 NERFINISHED ⓘ
SMN protein ⓘ
UNRIP protein NERFINISHED ⓘ
identifiedIn Drosophila melanogaster NERFINISHED ⓘ
Homo sapiens ⓘ
Mus musculus NERFINISHED ⓘ
interactsWith Sm proteins NERFINISHED ⓘ
coilin ⓘ
snRNAs ⓘ
spliceosomal components ⓘ
locatedIn Cajal bodies NERFINISHED ⓘ
cytoplasm ⓘ
gems (Gemini of Cajal bodies) NERFINISHED ⓘ
nucleus ⓘ
molecularFunction RNA binding ⓘ
chaperone activity in snRNP assembly ⓘ
protein binding ⓘ
partOf RNA splicing machinery ⓘ
spliceosomal snRNP assembly pathway ⓘ
regulates snRNP nuclear import ⓘ
snRNP stability ⓘ
spliceosome assembly ⓘ
requiresComponent SMN1 gene product ⓘ
SMN2 gene product ⓘ
subcellularDistributionDependsOn SMN protein concentration ⓘ

Referenced by (2)

Full triples — surface form annotated when it differs from this entity's canonical label.

SMN2 → alsoKnownAs → SMN complex ⓘ
this entity surface form: SMNc
survival motor neuron protein → formsComplexWith → SMN complex ⓘ
subject surface form: Survival motor neuron protein