SMCR8-WDR41 complex
E561102
The SMCR8-WDR41 complex is a protein assembly that partners with C9orf72 to regulate autophagy and lysosomal function, particularly in the context of neurodegenerative disease mechanisms.
Statements (35)
| Predicate | Object |
|---|---|
| instanceOf |
macromolecular complex
ⓘ
protein complex ⓘ |
| associatedWith |
C9orf72-related neurodegeneration
ⓘ
amyotrophic lateral sclerosis ⓘ frontotemporal dementia ⓘ neurodegenerative disease mechanisms ⓘ |
| binds | C9orf72 protein NERFINISHED ⓘ |
| disruptionLeadsTo |
abnormal lysosomal morphology
ⓘ
accumulation of autophagic substrates ⓘ impaired autophagy ⓘ |
| formsComplexWith | C9orf72 protein NERFINISHED ⓘ |
| hasFunction |
regulator of small GTPase signaling
ⓘ
scaffold for C9orf72 ⓘ |
| hasPart |
SMCR8 protein
NERFINISHED
ⓘ
WDR41 protein ⓘ |
| interactsWith |
Rab GTPases
NERFINISHED
ⓘ
autophagy machinery components ⓘ |
| involvedIn |
cellular response to nutrient status
ⓘ
protein degradation pathways ⓘ |
| isAffectedBy | C9orf72 hexanucleotide repeat expansion ⓘ |
| isComponentOf | C9orf72–SMCR8–WDR41 complex NERFINISHED ⓘ |
| localizesTo |
cytoplasm
ⓘ
late endosome ⓘ lysosome ⓘ |
| participatesIn |
autophagosome–lysosome fusion regulation
ⓘ
autophagy regulation ⓘ lysosomal function regulation ⓘ lysosome homeostasis ⓘ |
| regulates |
TFEB activity
ⓘ
autophagic flux ⓘ lysosomal biogenesis ⓘ lysosomal trafficking ⓘ mTORC1 signaling at lysosomes ⓘ |
| studiedIn |
mouse models of C9orf72 deficiency
ⓘ
neuronal cells ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.