Gemin4

E561086
SMN complex component protein

Gemin4 is a core component of the SMN (survival motor neuron) complex involved in the assembly and maturation of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.

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Statements (40)

Predicate Object
instanceOf SMN complex component ⓘ
protein ⓘ
alias GEMIN4 NERFINISHED ⓘ
gem-associated protein 4 NERFINISHED ⓘ
associatedWithDiseaseMechanism defective snRNP biogenesis ⓘ
associatedWithPathway RNA transport and processing pathways ⓘ
spliceosome pathway ⓘ
associatedWithProcess RNA processing ⓘ
mRNA splicing via spliceosome ⓘ
spliceosomal snRNP biogenesis ⓘ
bindsTo Gemin2 NERFINISHED ⓘ
Gemin3 NERFINISHED ⓘ
SMN protein NERFINISHED ⓘ
small nuclear RNAs ⓘ
biologicalRole maintenance of snRNP levels ⓘ
regulation of spliceosome composition ⓘ
cellularComponent SMN–Gemin complex NERFINISHED ⓘ
ribonucleoprotein complex ⓘ
conservedIn vertebrates ⓘ
encodedBy GEMIN4 gene NERFINISHED ⓘ
essentialFor efficient pre-mRNA splicing ⓘ
proper assembly of spliceosomal snRNPs ⓘ
inComplexWith Gemin5 NERFINISHED ⓘ
Gemin6 NERFINISHED ⓘ
Gemin7 ⓘ
Gemin8 ⓘ
SMN1 protein NERFINISHED ⓘ
locatedIn Gems (Gemini of Cajal bodies) NERFINISHED ⓘ
cytoplasm ⓘ
nucleus ⓘ
molecularFunction RNA binding ⓘ
protein binding ⓘ
organism Homo sapiens NERFINISHED ⓘ
participatesIn SMN complex assembly ⓘ
pre-mRNA splicing ⓘ
snRNP assembly ⓘ
snRNP maturation ⓘ
partOf SMN complex NERFINISHED ⓘ
subcellularLocalization Cajal body-associated structures ⓘ
nuclear bodies ⓘ

Referenced by (1)

Full triples — surface form annotated when it differs from this entity's canonical label.

survival motor neuron protein → formsComplexWith → Gemin4 ⓘ
subject surface form: Survival motor neuron protein