Gemin2
E561085
Gemin2 is a core component of the SMN complex that plays a crucial role in the assembly of small nuclear ribonucleoproteins (snRNPs) essential for pre-mRNA splicing.
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
SMN complex component
ⓘ
protein ⓘ |
| alternativeName |
SIP1
NERFINISHED
ⓘ
gem-associated protein 2 NERFINISHED ⓘ |
| associatedWith | spinal muscular atrophy pathway ⓘ |
| binds | SMN Tudor domain-containing region ⓘ |
| biologicalProcess |
RNP complex biogenesis
ⓘ
U snRNP biogenesis ⓘ mRNA processing ⓘ pre-mRNA splicing ⓘ regulation of RNA splicing ⓘ small nuclear RNA processing ⓘ snRNP assembly ⓘ spliceosomal snRNP complex assembly ⓘ |
| cellularComponent |
Cajal body
NERFINISHED
ⓘ
cytoplasm ⓘ germ cell granule ⓘ nucleus ⓘ |
| chromosomalLocation | human chromosome 14q21 ⓘ |
| conservedIn | eukaryotes ⓘ |
| encodedBy | GEMIN2 gene NERFINISHED ⓘ |
| foundInTaxon | Homo sapiens ⓘ |
| hasDomain | coiled-coil region ⓘ |
| interactsWith |
Gemin3
NERFINISHED
ⓘ
Gemin4 NERFINISHED ⓘ SMN protein NERFINISHED ⓘ Sm proteins NERFINISHED ⓘ small nuclear RNAs ⓘ |
| involvedInComplexAssembly | Sm core assembly on snRNA ⓘ |
| isEssentialFor | snRNP biogenesis in metazoans ⓘ |
| length | 280 amino acids (human) ⓘ |
| localization | nuclear gems ⓘ |
| molecularFunction |
RNA binding
ⓘ
protein binding ⓘ |
| orthologIn |
Caenorhabditis elegans
NERFINISHED
ⓘ
Drosophila melanogaster NERFINISHED ⓘ Mus musculus ⓘ |
| partOf | SMN complex NERFINISHED ⓘ |
| regulates | snRNP core particle formation ⓘ |
| requiredFor | efficient spliceosome assembly ⓘ |
| roleIn |
assembly of small nuclear ribonucleoproteins
ⓘ
spliceosome function ⓘ |
| stabilizes | SMN complex NERFINISHED ⓘ |
| subunitOf | survival motor neuron (SMN) complex NERFINISHED ⓘ |
| uniprotId | Q9H840 ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein