gems (Gemini of Cajal bodies)
E561084
Gems (Gemini of Cajal bodies) are nuclear structures closely associated with Cajal bodies that are involved in the biogenesis and assembly of small nuclear ribonucleoproteins (snRNPs) and RNA processing.
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf | nuclear body ⓘ |
| alsoKnownAs |
GEMs
NERFINISHED
ⓘ
Gemini of Cajal bodies NERFINISHED ⓘ |
| associatedDiseaseMechanism | defective snRNP biogenesis in spinal muscular atrophy ⓘ |
| associatedWith |
Cajal body-specific RNAs
ⓘ
U snRNAs ⓘ spliceosomal snRNPs ⓘ |
| closelyAssociatedWith | Cajal bodies NERFINISHED ⓘ |
| considered | subtype of nuclear speckle-like structure ⓘ |
| contains |
Gemin proteins
NERFINISHED
ⓘ
Gemin2 NERFINISHED ⓘ Gemin3 NERFINISHED ⓘ Gemin4 NERFINISHED ⓘ Gemin5 NERFINISHED ⓘ Gemin6 NERFINISHED ⓘ Gemin7 NERFINISHED ⓘ Gemin8 ⓘ SMN complex NERFINISHED ⓘ survival motor neuron protein NERFINISHED ⓘ |
| dependentOn | SMN protein levels ⓘ |
| disruptedIn | spinal muscular atrophy ⓘ |
| distinguishedBy | enrichment of SMN protein ⓘ |
| dynamicDuring | cell cycle ⓘ |
| foundIn |
mammalian cell nuclei
ⓘ
vertebrate cells ⓘ |
| functionallyRelatedTo | spliceosome assembly ⓘ |
| identifiedBy | co-localization of SMN and Gemin proteins ⓘ |
| involvedIn |
RNA processing
ⓘ
pre-mRNA splicing regulation ⓘ small nuclear ribonucleoprotein biogenesis ⓘ snRNP assembly ⓘ |
| locatedIn | cell nucleus ⓘ |
| markerProtein | SMN ⓘ |
| morphologicallySimilarTo | Cajal bodies NERFINISHED ⓘ |
| numberVaryWith |
cell type
ⓘ
metabolic activity ⓘ |
| participatesIn |
assembly of Sm core on snRNAs
ⓘ
trafficking of snRNPs in nucleus ⓘ |
| playsRoleIn |
RNP metabolism
ⓘ
snRNP maturation ⓘ snRNP recycling ⓘ |
| researchModel | HeLa cells NERFINISHED ⓘ |
| spatiallyOverlapsWith | Cajal bodies NERFINISHED ⓘ |
| subcellularLocalization | nuclear matrix-associated regions ⓘ |
| visualizedBy | immunofluorescence microscopy ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein