Cajal bodies
E561083
Cajal bodies are dynamic nuclear suborganelles involved in the biogenesis and maturation of small nuclear ribonucleoproteins (snRNPs) and other RNA-processing factors.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
biomolecular condensate
ⓘ
membraneless organelle ⓘ nuclear suborganelle ⓘ |
| alsoKnownAs | coiled bodies NERFINISHED ⓘ |
| associatedWith |
RNA polymerase II transcription
ⓘ
small nuclear RNAs ⓘ small nucleolar RNAs ⓘ telomerase RNA component ⓘ |
| closelyAssociatedWith | nucleolus ⓘ |
| contains |
Nopp140
NERFINISHED
ⓘ
SMN complex NERFINISHED ⓘ coilin ⓘ fibrillarin NERFINISHED ⓘ scaRNAs ⓘ spliceosomal snRNPs ⓘ survival motor neuron protein NERFINISHED ⓘ |
| disassemblesDuring | mitosis ⓘ |
| dysfunctionAssociatedWith |
neurodegenerative diseases
ⓘ
spinal muscular atrophy ⓘ |
| formsBy | liquid–liquid phase separation ⓘ |
| foundIn |
Drosophila cells
ⓘ
plant cells ⓘ vertebrate cells ⓘ |
| hasCharacteristic |
dynamic
ⓘ
membrane-less ⓘ spherical ⓘ variable number per nucleus ⓘ |
| hasMarkerProtein | coilin ⓘ |
| identifiedBy | anti-coilin antibodies ⓘ |
| involvedIn |
RNA processing
ⓘ
small nuclear ribonucleoprotein assembly ⓘ small nucleolar RNP biogenesis ⓘ snRNP biogenesis ⓘ snRNP maturation ⓘ spliceosome assembly ⓘ telomerase RNP biogenesis ⓘ |
| locatedIn |
cell nucleus
ⓘ
nucleoplasm ⓘ |
| namedAfter | Santiago Ramón y Cajal NERFINISHED ⓘ |
| numberDependsOn |
cell cycle stage
ⓘ
transcriptional activity ⓘ |
| playsRoleIn |
RNP quality control
ⓘ
snRNA 2'-O-methylation ⓘ snRNA modification ⓘ snRNA pseudouridylation ⓘ |
| reassemblesDuring | G1 phase ⓘ |
| subclassOf | nuclear body ⓘ |
| visualizedBy |
electron microscopy
ⓘ
immunofluorescence microscopy ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Survival motor neuron protein