blood–brain barrier
E559473
The blood–brain barrier is a highly selective, semipermeable border of endothelial cells that protects the brain by restricting and regulating the passage of substances from the bloodstream into the central nervous system.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
neurovascular structure
ⓘ
physiological barrier ⓘ selective permeability barrier ⓘ |
| associatedWith |
Alzheimer's disease
NERFINISHED
ⓘ
brain tumors ⓘ multiple sclerosis ⓘ stroke ⓘ |
| canBeDisruptedBy |
hypertension
ⓘ
inflammation ⓘ ischemia ⓘ neurodegenerative diseases ⓘ traumatic brain injury ⓘ |
| composedOf |
astrocyte end-feet
ⓘ
basement membrane ⓘ brain endothelial cells ⓘ pericytes ⓘ |
| developsDuring | embryonic and early postnatal development ⓘ |
| differsFrom | blood–cerebrospinal fluid barrier ⓘ |
| formedBy | endothelial cells of brain capillaries ⓘ |
| hasAbbreviation | BBB ⓘ |
| hasClinicalRelevance |
limits delivery of therapeutic drugs to the brain
ⓘ
target for drug delivery strategies ⓘ |
| hasFeature |
high electrical resistance
ⓘ
low pinocytotic activity ⓘ tight junctions between endothelial cells ⓘ |
| hasFunction |
maintain central nervous system homeostasis
ⓘ
protect brain from toxins ⓘ regulate transport of substances between blood and brain ⓘ restrict passage of large and hydrophilic molecules ⓘ |
| hasMechanism |
efflux transporters such as P-glycoprotein
ⓘ
paracellular restriction via tight junctions ⓘ receptor-mediated transcytosis ⓘ transcellular transport via specific carriers ⓘ |
| isPresentIn | vertebrates ⓘ |
| locatedIn | brain microvasculature ⓘ |
| partOf |
central nervous system
ⓘ
neurovascular unit NERFINISHED ⓘ |
| permitsPassageOf |
certain amino acids via transporters
ⓘ
gases such as oxygen and carbon dioxide ⓘ glucose via specific transporters ⓘ small lipophilic molecules ⓘ water via aquaporin channels ⓘ |
| regulatedBy |
astrocytes
ⓘ
neurons ⓘ pericytes ⓘ |
| restrictsPassageOf |
large plasma proteins
ⓘ
many drugs ⓘ most blood-borne pathogens ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.