JC virus
E559470
JC virus is a human polyomavirus that typically causes asymptomatic infection but can lead to severe demyelinating brain disease in immunocompromised individuals.
Statements (55)
| Predicate | Object |
|---|---|
| instanceOf |
DNA virus
ⓘ
human polyomavirus ⓘ virus ⓘ |
| abbreviation | JCV NERFINISHED ⓘ |
| alsoKnownAs | John Cunningham virus NERFINISHED ⓘ |
| associatedDisease | progressive multifocal leukoencephalopathy ⓘ |
| biosafetyLevel | 2 ⓘ |
| capsidSymmetry | icosahedral ⓘ |
| cellEntryReceptor | serotonin receptor 5-HT2A ⓘ |
| diagnosticMethod |
PCR of cerebrospinal fluid
ⓘ
brain MRI ⓘ brain biopsy ⓘ |
| discoveredBy |
Chou
NERFINISHED
ⓘ
ZuRhein NERFINISHED ⓘ |
| discoveryYear | 1971 ⓘ |
| encodesProtein |
VP1
NERFINISHED
ⓘ
VP2 NERFINISHED ⓘ VP3 NERFINISHED ⓘ agnoprotein ⓘ large T antigen ⓘ small t antigen ⓘ |
| enveloped | no ⓘ |
| family | Polyomaviridae NERFINISHED ⓘ |
| genomeSegment |
early region
ⓘ
late region ⓘ |
| genomeStructure | circular DNA ⓘ |
| genomeType | double-stranded DNA ⓘ |
| genus | Polyomavirus NERFINISHED ⓘ |
| host |
Homo sapiens
ⓘ
human ⓘ |
| latencySite |
bone marrow
ⓘ
kidney ⓘ lymphoid tissue ⓘ |
| namedAfter | John Cunningham NERFINISHED ⓘ |
| oncogenicPotential | possible ⓘ |
| pathology | demyelination ⓘ |
| prevalence | high seroprevalence in adults ⓘ |
| primaryInfectionOutcome | asymptomatic infection ⓘ |
| reactivationCondition | immunosuppression ⓘ |
| reactivationOutcome |
central nervous system infection
ⓘ
viremia ⓘ |
| riskGroup |
AIDS patients
ⓘ
immunocompromised individuals ⓘ organ transplant recipients ⓘ patients on natalizumab ⓘ patients on other immunosuppressive therapies ⓘ |
| seroprevalenceRange | 50-80% of adults ⓘ |
| targetOrgan | brain ⓘ |
| taxonRank | species ⓘ |
| transmissionRoute |
oral-fecal route
ⓘ
respiratory route ⓘ urinary route ⓘ |
| tropism |
astrocytes
ⓘ
kidney epithelial cells ⓘ oligodendrocytes ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.