mRNA vaccine
E523135
An mRNA vaccine is a type of vaccine that uses a small piece of messenger RNA to instruct cells to produce a viral protein, triggering an immune response without using a live virus.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| MRNA | 1 |
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
biological product
ⓘ
medical technology ⓘ vaccine type ⓘ |
| canBe |
monovalent
ⓘ
multivalent ⓘ |
| canBeFormulatedAs |
modRNA vaccine
ⓘ
self-amplifying mRNA vaccine ⓘ |
| canTarget |
Zika virus
NERFINISHED
ⓘ
cancer neoantigens ⓘ cytomegalovirus NERFINISHED ⓘ influenza virus ⓘ rabies virus ⓘ respiratory syncytial virus NERFINISHED ⓘ |
| doesNotContain | live virus ⓘ |
| doesNotIntegrateInto | host DNA ⓘ |
| encodes | viral protein ⓘ |
| hasAdvantage |
flexible antigen design
ⓘ
no need to grow pathogen in culture ⓘ potential for quick updates against variants ⓘ rapid design and development ⓘ |
| hasComponent |
3′ untranslated region
ⓘ
5′ cap structure ⓘ 5′ untranslated region ⓘ lipid nanoparticle excipients ⓘ nucleoside-modified mRNA ⓘ poly(A) tail ⓘ |
| hasMechanism | instructs host cells to produce antigen ⓘ |
| hasSafetyProfile | generally transient local and systemic reactions ⓘ |
| induces | immune response ⓘ |
| isDeliveredBy | injection ⓘ |
| isDeliveredWith | lipid nanoparticles ⓘ |
| isRegulatedAs | biological medicinal product ⓘ |
| isSubjectOf | intense clinical research ⓘ |
| isTranscribedIn | cell cytoplasm ⓘ |
| isTranslatedBy | host ribosomes ⓘ |
| isUsedIn | mass immunization campaigns ⓘ |
| mayRequire |
booster doses
ⓘ
prime-boost schedule ⓘ |
| produces | antigenic protein in host cells ⓘ |
| requires | cold chain storage ⓘ |
| stimulates |
B cell response
ⓘ
T cell response ⓘ antibody production ⓘ cell-mediated immunity ⓘ |
| targets |
SARS-CoV-2
NERFINISHED
ⓘ
infectious diseases ⓘ |
| usesMolecule | messenger RNA ⓘ |
| wasPioneeredIn | early 1990s ⓘ |
| wasScaledFor | COVID-19 pandemic NERFINISHED ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
MRNA