chronic traumatic encephalopathy
E509114
Chronic traumatic encephalopathy is a progressive, degenerative brain disease associated with repeated head impacts, most commonly identified in contact sport athletes and military veterans.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| Concussion | 1 |
Statements (68)
| Predicate | Object |
|---|---|
| instanceOf |
brain disease
ⓘ
neurodegenerative disease ⓘ tauopathy ⓘ |
| affects | brain ⓘ |
| associatedWith |
American football
ⓘ
blast exposure ⓘ boxing ⓘ contact sports ⓘ ice hockey ⓘ military service ⓘ repetitive concussive injuries ⓘ repetitive head impacts ⓘ rugby ⓘ soccer heading ⓘ subconcussive head impacts ⓘ |
| diagnosedBy | postmortem neuropathological examination ⓘ |
| differsFrom | Alzheimer's disease in distribution of tau pathology ⓘ |
| firstDescribedIn | boxers ⓘ |
| formerlyKnownAs | punch-drunk syndrome NERFINISHED ⓘ |
| hasAbbreviation | CTE NERFINISHED ⓘ |
| hasCharacteristic |
degenerative
ⓘ
progressive ⓘ |
| hasCourse | progressive neurodegeneration ⓘ |
| hasDiagnosticCriterion |
irregularly distributed tau pathology at the depths of cortical sulci
ⓘ
perivascular accumulation of phosphorylated tau in neurons and astrocytes ⓘ |
| hasNoCurrentTreatment | disease-modifying therapy ⓘ |
| hasOnset | years after repetitive head trauma ⓘ |
| hasPathology |
abnormal tau protein deposition
ⓘ
astrocytic tangles ⓘ atrophy of cerebral cortex ⓘ atrophy of medial temporal lobe ⓘ cavum septum pellucidum ⓘ neurofibrillary tangles ⓘ perivascular tau deposition ⓘ |
| hasRiskFactor |
blast exposure in military settings
ⓘ
high number of head impacts ⓘ insufficient recovery time between head injuries ⓘ long duration of contact sports participation ⓘ repeated concussions ⓘ subconcussive impacts ⓘ |
| hasSymptom |
aggression
ⓘ
anxiety ⓘ apathy ⓘ behavioral changes ⓘ cognitive decline ⓘ depression ⓘ emotional lability ⓘ executive dysfunction ⓘ gait disturbance ⓘ impaired judgment ⓘ impulsivity ⓘ memory impairment ⓘ mood disturbances ⓘ parkinsonism ⓘ personality changes ⓘ speech difficulties ⓘ substance misuse ⓘ suicidal behavior ⓘ |
| historicallyAssociatedWith | dementia pugilistica ⓘ |
| managedBy | symptomatic treatment ⓘ |
| preventionStrategy |
improved concussion protocols
ⓘ
reduction of repetitive head impacts ⓘ rule changes in contact sports ⓘ use of protective equipment ⓘ |
| resembles | Alzheimer's disease in some pathological features ⓘ |
| studiedBy |
military medicine researchers
ⓘ
neuropathologists ⓘ sports medicine researchers ⓘ |
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Concussion