Inmazeb
E468966
FDA-approved drug
antiviral drug
biologic medicinal product
monoclonal antibody cocktail
prescription drug
Inmazeb is an FDA-approved monoclonal antibody cocktail used to treat infections caused by Zaire ebolavirus.
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
FDA-approved drug
ⓘ
antiviral drug ⓘ biologic medicinal product ⓘ monoclonal antibody cocktail ⓘ prescription drug ⓘ |
| adverseEffect |
chills
ⓘ
diarrhea ⓘ hypotension ⓘ hypoxia ⓘ nausea ⓘ pyrexia ⓘ shivering ⓘ tachycardia ⓘ vomiting ⓘ |
| approvalDate | 2020 ⓘ |
| approvalStatus | approved ⓘ |
| approvalType | FDA-approved ⓘ |
| blackBoxWarning |
hypersensitivity reactions
ⓘ
infusion-related reactions ⓘ |
| countryOfApproval | United States of America NERFINISHED ⓘ |
| dosageForm | solution for intravenous infusion ⓘ |
| hasATCCode | J06BD ⓘ |
| hasComponent |
atoltivimab
NERFINISHED
ⓘ
maftivimab NERFINISHED ⓘ odesivimab NERFINISHED ⓘ |
| hasINN |
atoltivimab
ⓘ
maftivimab NERFINISHED ⓘ odesivimab NERFINISHED ⓘ |
| indication | treatment of infection caused by Zaire ebolavirus ⓘ |
| isCombinationProduct | true ⓘ |
| isFirstInClass | first FDA-approved treatment for Zaire ebolavirus infection ⓘ |
| isHumanMonoclonalAntibody | true ⓘ |
| lactationUse | caution advised ⓘ |
| legalStatus | prescription only ⓘ |
| mechanismOfAction |
binds to Zaire ebolavirus glycoprotein
ⓘ
neutralizes Zaire ebolavirus ⓘ |
| pharmacologicalClass |
antiviral monoclonal antibody
ⓘ
monoclonal antibody ⓘ |
| pregnancyCategory | insufficient human data ⓘ |
| regulatoryAgencyApproval | U.S. Food and Drug Administration NERFINISHED ⓘ |
| riskPopulation | hospitalized patients with Zaire ebolavirus infection ⓘ |
| routeOfAdministration | intravenous infusion ⓘ |
| storageCondition | refrigerated ⓘ |
| targetOrganism | Zaire ebolavirus NERFINISHED ⓘ |
| therapeuticArea |
infectious disease
ⓘ
virology ⓘ |
| treats |
Ebola virus disease caused by Zaire ebolavirus
ⓘ
Zaire ebolavirus infection ⓘ |
| usedIn | treatment of Ebola virus disease outbreaks ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.