major histocompatibility complex (MHC)
E461225
The major histocompatibility complex (MHC) is a set of cell-surface proteins essential for the immune system to recognize foreign molecules and present antigens to T cells, playing a central role in adaptive immunity and transplant compatibility.
All labels observed (1)
| Label | Occurrences |
|---|---|
| major histocompatibility complex (MHC) canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4667792 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: major histocompatibility complex (MHC) Context triple: [Rolf Zinkernagel, hasResearchFocus, major histocompatibility complex (MHC)]
-
A.
HLA
HLA is the three-letter IATA airport code for Lanseria International Airport, a major privately owned airport serving the Johannesburg region in South Africa.
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B.
B lymphocytes
B lymphocytes are a type of white blood cell central to the adaptive immune system, responsible for producing antibodies and mediating humoral immunity.
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C.
ABO blood group system
The ABO blood group system is the primary human blood classification method based on the presence or absence of specific antigens on red blood cells, crucial for safe blood transfusions and organ transplantation.
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D.
ISOTYPE
ISOTYPE is a pictorial language and visual communication system developed in the 1920s–30s to present complex social and economic data through standardized icons and charts.
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E.
LHM
LHM is the station code for Lillehammer railway station in Norway.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: major histocompatibility complex (MHC) Target entity description: The major histocompatibility complex (MHC) is a set of cell-surface proteins essential for the immune system to recognize foreign molecules and present antigens to T cells, playing a central role in adaptive immunity and transplant compatibility.
-
A.
HLA
HLA is the three-letter IATA airport code for Lanseria International Airport, a major privately owned airport serving the Johannesburg region in South Africa.
-
B.
B lymphocytes
B lymphocytes are a type of white blood cell central to the adaptive immune system, responsible for producing antibodies and mediating humoral immunity.
-
C.
ABO blood group system
The ABO blood group system is the primary human blood classification method based on the presence or absence of specific antigens on red blood cells, crucial for safe blood transfusions and organ transplantation.
-
D.
ISOTYPE
ISOTYPE is a pictorial language and visual communication system developed in the 1920s–30s to present complex social and economic data through standardized icons and charts.
-
E.
LHM
LHM is the station code for Lillehammer railway station in Norway.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
cell-surface molecule
ⓘ
gene cluster ⓘ immune system component ⓘ protein complex ⓘ |
| abbreviatedAs | HLA in humans ⓘ |
| alsoKnownAs | MHC NERFINISHED ⓘ |
| associatedWith |
HLA-B27
NERFINISHED
ⓘ
HLA-DRB1 alleles ⓘ ankylosing spondylitis risk ⓘ celiac disease risk ⓘ type 1 diabetes risk ⓘ |
| binds |
foreign peptides
ⓘ
peptide antigens ⓘ self peptides ⓘ |
| encodedBy | MHC genes ⓘ |
| evolvedUnder | balancing selection ⓘ |
| expressedOn | cell surface ⓘ |
| foundIn |
humans
ⓘ
jawed vertebrates ⓘ mammals ⓘ |
| hasFunction |
interact with CD4 and CD8 co-receptors
ⓘ
present endogenous antigens via class I ⓘ present exogenous antigens via class II ⓘ shape T cell repertoire during thymic selection ⓘ |
| hasPart |
MHC class I
ⓘ
MHC class II ⓘ MHC class III ⓘ |
| hasProperty |
co-dominantly expressed
ⓘ
highly polymorphic ⓘ polygenic ⓘ |
| hasRegion |
class I region
ⓘ
class II region ⓘ class III region ⓘ |
| inHumansCalled | human leukocyte antigen system NERFINISHED ⓘ |
| involvedIn |
autoimmune disease susceptibility
ⓘ
graft rejection ⓘ mate selection in some species ⓘ pathogen resistance ⓘ tissue typing ⓘ |
| locatedOn | chromosome 6 in humans ⓘ |
| playsRoleIn |
T cell activation
ⓘ
adaptive immunity ⓘ antigen presentation ⓘ immune surveillance ⓘ self–non-self discrimination ⓘ transplant compatibility ⓘ |
| recognizedBy |
CD4+ T cells
NERFINISHED
ⓘ
CD8+ T cells NERFINISHED ⓘ T cell receptors ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: major histocompatibility complex (MHC) Description of subject: The major histocompatibility complex (MHC) is a set of cell-surface proteins essential for the immune system to recognize foreign molecules and present antigens to T cells, playing a central role in adaptive immunity and transplant compatibility.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Rolf Zinkernagel