major histocompatibility complex (MHC)
E461225
The major histocompatibility complex (MHC) is a set of cell-surface proteins essential for the immune system to recognize foreign molecules and present antigens to T cells, playing a central role in adaptive immunity and transplant compatibility.
Observed surface forms (1)
| Surface form | Occurrences |
|---|---|
| major histocompatibility complex | 0 |
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
cell-surface molecule
ⓘ
gene cluster ⓘ immune system component ⓘ protein complex ⓘ |
| abbreviatedAs | HLA in humans ⓘ |
| alsoKnownAs | MHC NERFINISHED ⓘ |
| associatedWith |
HLA-B27
NERFINISHED
ⓘ
HLA-DRB1 alleles ⓘ ankylosing spondylitis risk ⓘ celiac disease risk ⓘ type 1 diabetes risk ⓘ |
| binds |
foreign peptides
ⓘ
peptide antigens ⓘ self peptides ⓘ |
| encodedBy | MHC genes ⓘ |
| evolvedUnder | balancing selection ⓘ |
| expressedOn | cell surface ⓘ |
| foundIn |
humans
ⓘ
jawed vertebrates ⓘ mammals ⓘ |
| hasFunction |
interact with CD4 and CD8 co-receptors
ⓘ
present endogenous antigens via class I ⓘ present exogenous antigens via class II ⓘ shape T cell repertoire during thymic selection ⓘ |
| hasPart |
MHC class I
ⓘ
MHC class II ⓘ MHC class III ⓘ |
| hasProperty |
co-dominantly expressed
ⓘ
highly polymorphic ⓘ polygenic ⓘ |
| hasRegion |
class I region
ⓘ
class II region ⓘ class III region ⓘ |
| inHumansCalled | human leukocyte antigen system NERFINISHED ⓘ |
| involvedIn |
autoimmune disease susceptibility
ⓘ
graft rejection ⓘ mate selection in some species ⓘ pathogen resistance ⓘ tissue typing ⓘ |
| locatedOn | chromosome 6 in humans ⓘ |
| playsRoleIn |
T cell activation
ⓘ
adaptive immunity ⓘ antigen presentation ⓘ immune surveillance ⓘ self–non-self discrimination ⓘ transplant compatibility ⓘ |
| recognizedBy |
CD4+ T cells
NERFINISHED
ⓘ
CD8+ T cells NERFINISHED ⓘ T cell receptors ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject surface form:
Rolf Zinkernagel