Notch
E459333
cell surface receptor
developmental gene
highly conserved protein
signaling receptor
single-pass transmembrane protein
Notch is a highly conserved signaling receptor and key developmental gene first characterized in fruit flies, where it regulates cell fate decisions and tissue patterning.
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
cell surface receptor
ⓘ
developmental gene ⓘ highly conserved protein ⓘ signaling receptor ⓘ single-pass transmembrane protein ⓘ |
| activatedBy |
Delta ligand
ⓘ
Jagged ligand ⓘ Serrate ligand ⓘ |
| associatedWith |
T-cell acute lymphoblastic leukemia
NERFINISHED
ⓘ
cancer ⓘ developmental disorders ⓘ |
| discoveredIn | early 20th century ⓘ |
| firstCharacterizedIn | Drosophila melanogaster NERFINISHED ⓘ |
| foundInOrganism | Drosophila melanogaster NERFINISHED ⓘ |
| geneticMutationPhenotypeInDrosophila | notched wing margins ⓘ |
| hasDomain |
EGF-like repeats
ⓘ
LIN-12/Notch repeats NERFINISHED ⓘ PEST sequence ⓘ RAM domain ⓘ ankyrin repeats ⓘ |
| hasMolecularFunction |
receptor activity
ⓘ
signal transducer activity ⓘ transcription regulation via intracellular domain ⓘ |
| interactsWith |
CSL transcription factor
ⓘ
Mastermind-like coactivator NERFINISHED ⓘ |
| locatedIn | plasma membrane ⓘ |
| namedAfter | notched wing phenotype in Drosophila ⓘ |
| orthologIn |
Caenorhabditis elegans
NERFINISHED
ⓘ
Danio rerio NERFINISHED ⓘ Homo sapiens NERFINISHED ⓘ Mus musculus NERFINISHED ⓘ |
| participatesIn |
Notch signaling pathway
NERFINISHED
ⓘ
angiogenesis ⓘ cell fate determination ⓘ hematopoiesis ⓘ lateral inhibition ⓘ neurogenesis ⓘ somitogenesis ⓘ stem cell maintenance ⓘ tissue patterning ⓘ |
| produces | Notch intracellular domain NERFINISHED ⓘ |
| regulates |
apoptosis
ⓘ
binary cell fate decisions ⓘ differentiation ⓘ proliferation ⓘ |
| requiresProcessingBy |
ADAM-family metalloprotease
NERFINISHED
ⓘ
gamma-secretase complex ⓘ |
| undergoes | regulated intramembrane proteolysis ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.