Notch
E459333
cell surface receptor
developmental gene
highly conserved protein
signaling receptor
single-pass transmembrane protein
Notch is a highly conserved signaling receptor and key developmental gene first characterized in fruit flies, where it regulates cell fate decisions and tissue patterning.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Notch canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4645726 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Notch Context triple: [Drosophila melanogaster, notableGene, Notch]
-
A.
Notch
Notch is the online alias of Markus Persson, the Swedish video game programmer best known as the original creator of Minecraft.
-
B.
Neo
Neo is the protagonist of the science fiction film series "The Matrix," a hacker who becomes humanity's prophesied savior within a simulated reality.
-
C.
notch
"notch" is the online alias of Markus Persson, the Swedish video game programmer best known as the original creator of Minecraft.
-
D.
Norval
Norval is a small historic village in Ontario, Canada, known for its scenic Credit River setting and association with author Lucy Maud Montgomery.
-
E.
Nico
"Nico" is a posthumous compilation album by the American rock band Blind Melon, featuring rare tracks, outtakes, and live recordings centered around late vocalist Shannon Hoon.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Notch Target entity description: Notch is a highly conserved signaling receptor and key developmental gene first characterized in fruit flies, where it regulates cell fate decisions and tissue patterning.
-
A.
Notch
Notch is the online alias of Markus Persson, the Swedish video game programmer best known as the original creator of Minecraft.
-
B.
Neo
Neo is the protagonist of the science fiction film series "The Matrix," a hacker who becomes humanity's prophesied savior within a simulated reality.
-
C.
notch
"notch" is the online alias of Markus Persson, the Swedish video game programmer best known as the original creator of Minecraft.
-
D.
Norval
Norval is a small historic village in Ontario, Canada, known for its scenic Credit River setting and association with author Lucy Maud Montgomery.
-
E.
Nico
"Nico" is a posthumous compilation album by the American rock band Blind Melon, featuring rare tracks, outtakes, and live recordings centered around late vocalist Shannon Hoon.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
cell surface receptor
ⓘ
developmental gene ⓘ highly conserved protein ⓘ signaling receptor ⓘ single-pass transmembrane protein ⓘ |
| activatedBy |
Delta ligand
ⓘ
Jagged ligand ⓘ Serrate ligand ⓘ |
| associatedWith |
T-cell acute lymphoblastic leukemia
NERFINISHED
ⓘ
cancer ⓘ developmental disorders ⓘ |
| discoveredIn | early 20th century ⓘ |
| firstCharacterizedIn | Drosophila melanogaster NERFINISHED ⓘ |
| foundInOrganism | Drosophila melanogaster NERFINISHED ⓘ |
| geneticMutationPhenotypeInDrosophila | notched wing margins ⓘ |
| hasDomain |
EGF-like repeats
ⓘ
LIN-12/Notch repeats NERFINISHED ⓘ PEST sequence ⓘ RAM domain ⓘ ankyrin repeats ⓘ |
| hasMolecularFunction |
receptor activity
ⓘ
signal transducer activity ⓘ transcription regulation via intracellular domain ⓘ |
| interactsWith |
CSL transcription factor
ⓘ
Mastermind-like coactivator NERFINISHED ⓘ |
| locatedIn | plasma membrane ⓘ |
| namedAfter | notched wing phenotype in Drosophila ⓘ |
| orthologIn |
Caenorhabditis elegans
NERFINISHED
ⓘ
Danio rerio NERFINISHED ⓘ Homo sapiens NERFINISHED ⓘ Mus musculus NERFINISHED ⓘ |
| participatesIn |
Notch signaling pathway
NERFINISHED
ⓘ
angiogenesis ⓘ cell fate determination ⓘ hematopoiesis ⓘ lateral inhibition ⓘ neurogenesis ⓘ somitogenesis ⓘ stem cell maintenance ⓘ tissue patterning ⓘ |
| produces | Notch intracellular domain NERFINISHED ⓘ |
| regulates |
apoptosis
ⓘ
binary cell fate decisions ⓘ differentiation ⓘ proliferation ⓘ |
| requiresProcessingBy |
ADAM-family metalloprotease
NERFINISHED
ⓘ
gamma-secretase complex ⓘ |
| undergoes | regulated intramembrane proteolysis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Notch Description of subject: Notch is a highly conserved signaling receptor and key developmental gene first characterized in fruit flies, where it regulates cell fate decisions and tissue patterning.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.