bithorax complex
E459331
The bithorax complex is a cluster of homeotic genes in Drosophila melanogaster that controls the identity and differentiation of the posterior thoracic and abdominal body segments.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
Hox gene cluster
ⓘ
gene cluster ⓘ homeotic gene complex ⓘ |
| adjacentTo | Antennapedia complex NERFINISHED ⓘ |
| associatedWithPhenotype |
bithorax mutation
ⓘ
homeotic transformation of halteres to wings ⓘ |
| controls |
abdominal segment identity
ⓘ
posterior thoracic segment identity ⓘ |
| discoveredInTaxon | Drosophila melanogaster NERFINISHED ⓘ |
| encodes |
Abdominal-B protein
NERFINISHED
ⓘ
Ultrabithorax protein NERFINISHED ⓘ abdominal-A protein ⓘ |
| expressedIn |
abdominal segments
ⓘ
posterior thoracic segments ⓘ |
| foundInTaxon | Drosophila melanogaster NERFINISHED ⓘ |
| genomicOrganization | clustered arrangement of multiple homeotic genes ⓘ |
| hasAllele |
abx mutation
ⓘ
bx mutation ⓘ pbx mutation ⓘ |
| hasBiologicalProcess |
anterior/posterior axis specification
ⓘ
pattern specification process ⓘ regulation of transcription ⓘ |
| hasGeneticElement |
cis-regulatory regions
ⓘ
enhancers ⓘ polycomb response elements ⓘ promoters ⓘ |
| hasHistoricalSignificance |
contributed to understanding of genetic control of development
ⓘ
provided evidence for colinearity of Hox genes ⓘ |
| hasMolecularFunction | DNA-binding transcription factor activity ⓘ |
| hasPart |
Abdominal-B
NERFINISHED
ⓘ
Ultrabithorax NERFINISHED ⓘ abdominal-A ⓘ |
| hasRegulatoryMechanism |
polycomb group repression
ⓘ
trithorax group activation ⓘ |
| hasSequenceFeature | homeobox domains in encoded proteins ⓘ |
| involvedIn |
embryonic development
ⓘ
imaginal disc development ⓘ segmental identity determination ⓘ |
| locatedOnChromosome | Drosophila melanogaster chromosome 3R NERFINISHED ⓘ |
| mapsToCytogeneticBand | Drosophila 89E region NERFINISHED ⓘ |
| orthologousTo | vertebrate posterior Hox gene clusters ⓘ |
| partOf | Drosophila Hox complex NERFINISHED ⓘ |
| regulates |
differentiation of abdominal segments
ⓘ
differentiation of posterior thoracic segments ⓘ homeotic transformation of segments ⓘ |
| studiedBy | Edward B. Lewis NERFINISHED ⓘ |
| subjectOf | homeotic mutation studies ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.