Bohr effect
E442121
The Bohr effect is a physiological phenomenon in which increases in carbon dioxide concentration and acidity reduce hemoglobin’s affinity for oxygen, thereby facilitating oxygen release to tissues.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Bohr effect canonical | 2 |
| Houssay phenomenon | 1 |
Statements (42)
| Predicate | Object |
|---|---|
| instanceOf |
hemoglobin-oxygen binding effect
ⓘ
physiological phenomenon ⓘ |
| affects | hemoglobin ⓘ |
| category |
hematology concept
ⓘ
respiratory physiology concept ⓘ |
| contrastedWith | Haldane effect ⓘ |
| dependsOn |
2,3-bisphosphoglycerate concentration
ⓘ
pH ⓘ partial pressure of carbon dioxide ⓘ temperature ⓘ |
| describes |
decrease in hemoglobin oxygen affinity with decreasing pH
ⓘ
decrease in hemoglobin oxygen affinity with increasing carbon dioxide ⓘ |
| discoveredBy | Christian Bohr NERFINISHED ⓘ |
| enhances | matching of oxygen supply to tissue demand ⓘ |
| historicalDiscoveryYear | 1904 ⓘ |
| importantFor |
oxygen delivery during exercise
ⓘ
oxygen delivery to metabolically active tissues ⓘ |
| influencedBy | metabolic activity of tissues ⓘ |
| involvesMolecule |
carbon dioxide
ⓘ
hemoglobin A ⓘ hydrogen ion ⓘ oxygen ⓘ |
| lessPronouncedIn | pulmonary capillaries ⓘ |
| mechanismInvolves |
formation of carbaminohemoglobin
ⓘ
increased carbon dioxide concentration ⓘ increased hydrogen ion concentration ⓘ protonation of hemoglobin ⓘ stabilization of deoxyhemoglobin ⓘ |
| morePronouncedIn | systemic capillaries ⓘ |
| namedAfter | Christian Bohr NERFINISHED ⓘ |
| occursIn |
blood
ⓘ
humans ⓘ vertebrates ⓘ |
| relatedTo |
acid-base balance
ⓘ
carbon dioxide transport ⓘ oxygen-hemoglobin dissociation curve ⓘ |
| relevance |
anesthesiology
ⓘ
clinical medicine ⓘ critical care medicine ⓘ respiratory physiology ⓘ |
| resultsIn |
facilitated oxygen release to tissues
ⓘ
rightward shift of oxygen-hemoglobin dissociation curve ⓘ |
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
Houssay phenomenon