Bicycle Therapeutics
E422484
Bicycle Therapeutics is a biotechnology company that develops novel therapeutics based on its proprietary bicyclic peptide (Bicycle®) platform, with a focus on targeted treatments for cancer and other serious diseases.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Bicycle Therapeutics canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4221591 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Bicycle Therapeutics Context triple: [Cambridge life sciences ecosystem, hasKeyCompany, Bicycle Therapeutics]
-
A.
Raleigh Bicycle Company
Raleigh Bicycle Company is a historic British bicycle manufacturer founded in the late 19th century that became one of the world’s largest and most influential bike brands.
-
B.
Records on Wheels
Records on Wheels was the original name of the Canadian entertainment company now known as Entertainment One, which began as a music and video distribution business.
-
C.
Santander Cycles
Santander Cycles is London’s public bicycle-sharing scheme, offering short-term bike rentals across the city through a network of docking stations.
-
D.
Ola Bike
Ola Bike is a bike-taxi service operated by Indian ride-hailing company Ola, providing affordable two-wheeler rides for short-distance urban travel.
-
E.
SmartRider
SmartRider is a reusable contactless smart card used for electronic fare payment across Transperth’s public transport network in Western Australia.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Bicycle Therapeutics Target entity description: Bicycle Therapeutics is a biotechnology company that develops novel therapeutics based on its proprietary bicyclic peptide (Bicycle®) platform, with a focus on targeted treatments for cancer and other serious diseases.
-
A.
Raleigh Bicycle Company
Raleigh Bicycle Company is a historic British bicycle manufacturer founded in the late 19th century that became one of the world’s largest and most influential bike brands.
-
B.
Records on Wheels
Records on Wheels was the original name of the Canadian entertainment company now known as Entertainment One, which began as a music and video distribution business.
-
C.
Santander Cycles
Santander Cycles is London’s public bicycle-sharing scheme, offering short-term bike rentals across the city through a network of docking stations.
-
D.
Ola Bike
Ola Bike is a bike-taxi service operated by Indian ride-hailing company Ola, providing affordable two-wheeler rides for short-distance urban travel.
-
E.
SmartRider
SmartRider is a reusable contactless smart card used for electronic fare payment across Transperth’s public transport network in Western Australia.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
biotechnology company
ⓘ
public company ⓘ |
| countryOfOrigin | United Kingdom ⓘ |
| develops |
Bicycle molecules
ⓘ
bicyclic peptide therapeutics ⓘ |
| focusesOn |
cancer therapeutics
ⓘ
oncology ⓘ targeted therapies ⓘ |
| foundedBy |
Christian Heinis
NERFINISHED
ⓘ
Gregory Winter NERFINISHED ⓘ Ian Tomlinson NERFINISHED ⓘ |
| foundedInPeriod | late 2000s ⓘ |
| hasClinicalCandidate |
BT1718
NERFINISHED
ⓘ
BT5528 NERFINISHED ⓘ BT7480 NERFINISHED ⓘ BT8009 NERFINISHED ⓘ |
| hasCollaboration |
AstraZeneca
NERFINISHED
ⓘ
Cancer Research UK NERFINISHED ⓘ Ionis Pharmaceuticals NERFINISHED ⓘ Novartis NERFINISHED ⓘ |
| hasIntellectualProperty | proprietary Bicycle peptide platform ⓘ |
| hasKeyPerson | Kevin Lee NERFINISHED ⓘ |
| hasOffice | Cambridge, Massachusetts, United States NERFINISHED ⓘ |
| hasTechnologyPlatform | Bicycle peptide platform ⓘ |
| hasTherapeuticArea |
other serious diseases
ⓘ
solid tumor cancers ⓘ |
| headquartersLocation | Cambridge, United Kingdom NERFINISHED ⓘ |
| industry | biotechnology ⓘ |
| mission | to develop targeted therapeutics for cancer and other serious diseases ⓘ |
| positionHeld | Kevin Lee – Chief Executive Officer NERFINISHED ⓘ |
| researchArea |
hematologic malignancies
ⓘ
immuno-oncology ⓘ solid tumors ⓘ |
| specializesIn |
bicyclic peptides
ⓘ
chemically constrained peptides ⓘ |
| stockTicker | BCYC NERFINISHED ⓘ |
| targets |
EphA2 (via BT5528)
ⓘ
MT1-MMP (via BT1718) NERFINISHED ⓘ Nectin-4 (via BT8009) NERFINISHED ⓘ Nectin-4/CD137 (via BT7480) NERFINISHED ⓘ |
| technologyCharacteristic |
high affinity target binding
ⓘ
rapid clearance from circulation ⓘ rapid tissue penetration ⓘ small, chemically synthesized peptides ⓘ |
| tradesOn | NASDAQ NERFINISHED ⓘ |
| usesApproach | phage display for peptide discovery ⓘ |
| usesModality |
tumor-targeted immune cell agonists
ⓘ
tumor-targeted radioconjugates ⓘ tumor-targeted toxin conjugates ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Bicycle Therapeutics Description of subject: Bicycle Therapeutics is a biotechnology company that develops novel therapeutics based on its proprietary bicyclic peptide (Bicycle®) platform, with a focus on targeted treatments for cancer and other serious diseases.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.