kynurenine aminotransferase III
E1160707
UNEXPLORED
Kynurenine aminotransferase III is an enzyme that catalyzes a transamination step in tryptophan degradation, contributing to the production of kynurenic acid and other metabolites in the kynurenine pathway.
All labels observed (2)
| Label | Occurrences |
|---|---|
| kynurenine aminotransferase III canonical | 1 |
| kynurenine aminotransferase IV | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T15478659 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: kynurenine aminotransferase III Context triple: [kynurenine pathway, involvesEnzyme, kynurenine aminotransferase III]
-
A.
kynurenine aminotransferase II
Kynurenine aminotransferase II is a pyridoxal phosphate-dependent enzyme that converts kynurenine to kynurenic acid, a neuroactive metabolite implicated in brain function and neurodegenerative disorders.
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B.
kynureninase
Kynureninase is a pyridoxal phosphate-dependent enzyme that catalyzes key steps in tryptophan degradation within the kynurenine pathway, contributing to the production of NAD⁺ and other metabolites.
-
C.
kynurenine pathway
The kynurenine pathway is the primary metabolic route for tryptophan degradation, producing several bioactive metabolites involved in immune regulation, neurobiology, and redox balance.
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D.
tryptophan 2,3-dioxygenase
Tryptophan 2,3-dioxygenase is a heme-containing enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of tryptophan, playing a key role in tryptophan metabolism and regulation.
-
E.
indoleamine 2,3-dioxygenase 2
Indoleamine 2,3-dioxygenase 2 is an immune-regulatory heme-containing enzyme that catalyzes the oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation and immune tolerance.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: kynurenine aminotransferase III Target entity description: Kynurenine aminotransferase III is an enzyme that catalyzes a transamination step in tryptophan degradation, contributing to the production of kynurenic acid and other metabolites in the kynurenine pathway.
-
A.
kynurenine aminotransferase II
Kynurenine aminotransferase II is a pyridoxal phosphate-dependent enzyme that converts kynurenine to kynurenic acid, a neuroactive metabolite implicated in brain function and neurodegenerative disorders.
-
B.
kynureninase
Kynureninase is a pyridoxal phosphate-dependent enzyme that catalyzes key steps in tryptophan degradation within the kynurenine pathway, contributing to the production of NAD⁺ and other metabolites.
-
C.
kynurenine pathway
The kynurenine pathway is the primary metabolic route for tryptophan degradation, producing several bioactive metabolites involved in immune regulation, neurobiology, and redox balance.
-
D.
tryptophan 2,3-dioxygenase
Tryptophan 2,3-dioxygenase is a heme-containing enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of tryptophan, playing a key role in tryptophan metabolism and regulation.
-
E.
indoleamine 2,3-dioxygenase 2
Indoleamine 2,3-dioxygenase 2 is an immune-regulatory heme-containing enzyme that catalyzes the oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation and immune tolerance.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
this entity surface form:
kynurenine aminotransferase IV