indoleamine 2,3-dioxygenase 2
E1159682
UNEXPLORED
Indoleamine 2,3-dioxygenase 2 is an immune-regulatory heme-containing enzyme that catalyzes the oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation and immune tolerance.
All labels observed (1)
| Label | Occurrences |
|---|---|
| indoleamine 2,3-dioxygenase 2 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T15478653 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: indoleamine 2,3-dioxygenase 2 Context triple: [kynurenine pathway, involvesEnzyme, indoleamine 2,3-dioxygenase 2]
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A.
aromatic L-amino acid decarboxylase
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
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B.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
C.
programmed cell death protein 1
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor on T cells that downregulates immune responses and promotes self-tolerance, making it a key target in cancer immunotherapy.
-
D.
catechol-O-methyltransferase
Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
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E.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: indoleamine 2,3-dioxygenase 2 Target entity description: Indoleamine 2,3-dioxygenase 2 is an immune-regulatory heme-containing enzyme that catalyzes the oxidative degradation of tryptophan along the kynurenine pathway, influencing inflammation and immune tolerance.
-
A.
aromatic L-amino acid decarboxylase
Aromatic L-amino acid decarboxylase is a pyridoxal phosphate–dependent enzyme that catalyzes the decarboxylation of aromatic L-amino acids to produce key neurotransmitters such as dopamine and serotonin.
-
B.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
C.
programmed cell death protein 1
Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor on T cells that downregulates immune responses and promotes self-tolerance, making it a key target in cancer immunotherapy.
-
D.
catechol-O-methyltransferase
Catechol-O-methyltransferase is an enzyme that inactivates catecholamine neurotransmitters and related drugs by transferring a methyl group to their catechol structures.
-
E.
IL-17A
IL-17A is a pro-inflammatory cytokine produced mainly by Th17 cells that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.