Sonogashira coupling
E1092230
UNEXPLORED
Sonogashira coupling is a palladium-catalyzed cross-coupling reaction that forms carbon–carbon bonds between terminal alkynes and aryl or vinyl halides, widely used in organic and materials synthesis.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Sonogashira coupling canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T14187051 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Sonogashira coupling Context triple: [Suzuki coupling, relatedReaction, Sonogashira coupling]
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A.
Suzuki coupling
Suzuki coupling is a widely used palladium-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organoboron compounds and organic halides, fundamental in organic synthesis and pharmaceutical chemistry.
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B.
Negishi coupling
Negishi coupling is a palladium- or nickel-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organozinc reagents and organic halides, widely used in organic synthesis.
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C.
Kumada coupling
Kumada coupling is a palladium- or nickel-catalyzed cross-coupling reaction between Grignard reagents and organic halides used to form carbon–carbon bonds in organic synthesis.
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D.
Buchwald–Hartwig amination
The Buchwald–Hartwig amination is a palladium-catalyzed cross-coupling reaction that forms carbon–nitrogen bonds by coupling aryl (or vinyl) halides with amines, widely used in the synthesis of pharmaceuticals and fine chemicals.
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E.
Heck reaction
The Heck reaction is a palladium-catalyzed cross-coupling between alkenes and aryl or vinyl halides, widely used in organic synthesis to form carbon–carbon bonds.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Sonogashira coupling Target entity description: Sonogashira coupling is a palladium-catalyzed cross-coupling reaction that forms carbon–carbon bonds between terminal alkynes and aryl or vinyl halides, widely used in organic and materials synthesis.
-
A.
Suzuki coupling
Suzuki coupling is a widely used palladium-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organoboron compounds and organic halides, fundamental in organic synthesis and pharmaceutical chemistry.
-
B.
Negishi coupling
Negishi coupling is a palladium- or nickel-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organozinc reagents and organic halides, widely used in organic synthesis.
-
C.
Kumada coupling
Kumada coupling is a palladium- or nickel-catalyzed cross-coupling reaction between Grignard reagents and organic halides used to form carbon–carbon bonds in organic synthesis.
-
D.
Buchwald–Hartwig amination
The Buchwald–Hartwig amination is a palladium-catalyzed cross-coupling reaction that forms carbon–nitrogen bonds by coupling aryl (or vinyl) halides with amines, widely used in the synthesis of pharmaceuticals and fine chemicals.
-
E.
Heck reaction
The Heck reaction is a palladium-catalyzed cross-coupling between alkenes and aryl or vinyl halides, widely used in organic synthesis to form carbon–carbon bonds.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.