Negishi coupling
E1088470
UNEXPLORED
Negishi coupling is a palladium- or nickel-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organozinc reagents and organic halides, widely used in organic synthesis.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Negishi coupling canonical | 3 |
How this entity was disambiguated
This entity first appeared as the object of triple T14187049 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Negishi coupling Context triple: [Suzuki coupling, relatedReaction, Negishi coupling]
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A.
Suzuki coupling
Suzuki coupling is a widely used palladium-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organoboron compounds and organic halides, fundamental in organic synthesis and pharmaceutical chemistry.
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B.
Buchwald–Hartwig amination
The Buchwald–Hartwig amination is a palladium-catalyzed cross-coupling reaction that forms carbon–nitrogen bonds by coupling aryl (or vinyl) halides with amines, widely used in the synthesis of pharmaceuticals and fine chemicals.
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C.
Heck reaction
The Heck reaction is a palladium-catalyzed cross-coupling between alkenes and aryl or vinyl halides, widely used in organic synthesis to form carbon–carbon bonds.
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D.
Williamson construction
Williamson construction is a classical combinatorial method for building large Hadamard matrices from smaller symmetric matrices with special algebraic properties.
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E.
Robinson annulation reaction
The Robinson annulation reaction is a classic organic chemistry transformation that forms six-membered rings by combining a Michael addition with an intramolecular aldol condensation, widely used in the synthesis of complex cyclic molecules and natural products.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Negishi coupling Target entity description: Negishi coupling is a palladium- or nickel-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organozinc reagents and organic halides, widely used in organic synthesis.
-
A.
Suzuki coupling
Suzuki coupling is a widely used palladium-catalyzed cross-coupling reaction that forms carbon–carbon bonds between organoboron compounds and organic halides, fundamental in organic synthesis and pharmaceutical chemistry.
-
B.
Buchwald–Hartwig amination
The Buchwald–Hartwig amination is a palladium-catalyzed cross-coupling reaction that forms carbon–nitrogen bonds by coupling aryl (or vinyl) halides with amines, widely used in the synthesis of pharmaceuticals and fine chemicals.
-
C.
Heck reaction
The Heck reaction is a palladium-catalyzed cross-coupling between alkenes and aryl or vinyl halides, widely used in organic synthesis to form carbon–carbon bonds.
-
D.
Williamson construction
Williamson construction is a classical combinatorial method for building large Hadamard matrices from smaller symmetric matrices with special algebraic properties.
-
E.
Robinson annulation reaction
The Robinson annulation reaction is a classic organic chemistry transformation that forms six-membered rings by combining a Michael addition with an intramolecular aldol condensation, widely used in the synthesis of complex cyclic molecules and natural products.
- F. None of above. chosen
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.