picrotoxin
E1046866
Picrotoxin is a highly toxic plant-derived compound that acts as a noncompetitive antagonist of GABA_A receptors, historically used as a stimulant and experimental convulsant in neuroscience research.
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
GABA_A receptor antagonist
ⓘ
chemical compound ⓘ neurotoxin ⓘ plant-derived toxin ⓘ |
| affectsOrganSystem |
cardiovascular system
ⓘ
central nervous system ⓘ respiratory system ⓘ |
| antagonizes | GABA-mediated inhibitory neurotransmission ⓘ |
| bindingSite | GABA_A receptor chloride channel pore ⓘ |
| effectOnIonFlux | inhibits chloride influx through GABA_A receptors ⓘ |
| hasChemicalNature | sesquiterpene ⓘ |
| hasComponent |
picrotin
ⓘ
picrotoxinin ⓘ |
| hasOrigin |
Anamirta cocculus
NERFINISHED
ⓘ
Cocculus indicus seeds ⓘ |
| hasPharmacologicalAction |
central nervous system stimulant
ⓘ
convulsant ⓘ noncompetitive GABA_A receptor antagonist ⓘ |
| hasPhysiologicalEffect |
causes convulsions
ⓘ
induces neuronal hyperexcitability ⓘ induces seizures at sufficient doses ⓘ |
| hasTaste | bitter ⓘ |
| hasToxicEffect |
cardiovascular disturbances
ⓘ
clonic and tonic-clonic seizures ⓘ nausea and vomiting ⓘ respiratory failure at high doses ⓘ tremors ⓘ |
| historicalUse |
central nervous system stimulant
ⓘ
experimental convulsant in neuroscience research ⓘ respiratory stimulant ⓘ |
| isHighlyToxic | true ⓘ |
| isNot | competitive GABA_A receptor antagonist ⓘ |
| mechanismOfAction | blocks GABA_A receptor-associated chloride channels ⓘ |
| modulatesNeurotransmission | GABAergic neurotransmission ⓘ |
| physicalStateAtRoomTemperature | solid ⓘ |
| requiresHandlingPrecautions | true ⓘ |
| riskClassification | highly toxic substance ⓘ |
| routeOfExposure |
intravenous
ⓘ
oral ⓘ |
| solubility |
poorly soluble in water
ⓘ
soluble in organic solvents ⓘ |
| targetsReceptor | GABA_A receptor ⓘ |
| usedAs | pharmacological tool compound ⓘ |
| usedIn |
GABA_A receptor pharmacology experiments
ⓘ
epilepsy models ⓘ neuroscience research ⓘ studies of inhibitory synaptic transmission ⓘ |
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.